2상모집 중단 (진행 중)

Comprehensive Analysis of Predictors of the Treatment With Pembrolizumab and Olaparib in Patients With Unresectable or Metastatic HER2 Negative Breast Cancer and a Deleterious Germline Mutation or a Homologous Recombination Deficiency (COMPRENDO

연구 개요

This study will examine the combination of pembrolizumab and olaparib in three populations. * Cohort 1: aBC patients with a germline mutation in BRCA1 or BRCA2, * cohort 2: aBC patients with a germline mutation in one of the moderate penetrance homologous repair genes (ATM, BARD1, CHEK2, FANCC, PALB2, RAD51C, RAD51D, SLX4, XRCC2), and * cohort 3: aBC patients with a HRD as assessed by whole genome sequencing.

스폰서: 협력: 머크(MSD)
적응증: Malignant Neoplasm of Breast, Breast Cancer
중재: Pembrolizumab Injection [Keytruda], Olaparib Oral Tablet [Lynparza]
목표 등록: 11명
시작일: 2022-07-30
완료(예정): 2026-02-01
등록번호: NCT05033756 · ClinicalTrials.gov ↗

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