큐리언트, CDK7 저해제 모카시클립·트로델비 병용 임상 IND 승인

기술 배경

관련 임상

• 2상모집 예정신규 항체-약물 복합체 사용 환자의 탈모 예방을 위한 두피 냉각
• 3상모집 예정임상 II-III기 삼중음성 초기 유방암 환자에서 사시투주맙 고비테칸+펨브롤리주맙 vs. 표준 화학요법 신보조요법 비교
• 3상모집 예정PARP억제제 1차 유지요법 중 진행된 난소암 환자에서 라루도타투그 드룩스테칸 ± 베바시주맙 임상시험
• 1/2상모집 중재발 또는 난치성 고형종양 소아 참가자를 대상으로 한 이피나타맙 데럭스테칸 임상시험(MK-9999-01D/LIGHTBEAM-U01)
• 2상모집 중HER2 Molecular Imaging With 89Zr-trastuzumab PET/CT as a Predictive Biomarker for Antibody-drug Conjugate Sequencing in Patients With Advanced HER2-positive Breast Cancer
• 단계 미표기모집 예정A Study to Evaluate Adverse Events and Change in Disease Activity of Mirvetuximab Soravtansine-gynx in Adults With Folate Receptor-Alpha Positive, Platinum-Resistant Ovarian Cancer in a Real-World Setting

관련 연구

• Journal of evidence-based medicine

  Comparative Cost-Effectiveness of First-Line Immunotherapy-Based Regimens for Advanced Triple-Negative Breast Cancer

• bioRxiv (프리프린트)

  A cross-modal generative model for incomplete and degradedprostate MRI with multicentre clinical validation

• Human vaccines & immunotherapeutics

  Cost-effectiveness analysis of disitamab vedotin plus toripalimab versus chemotherapy as first-line treatment for HER2-expressing advanced urothelial cancer

• Cancer chemotherapy and pharmacology

  CDCP1-targeted antibody-drug conjugates and immunocytokines for cancer therapy

• Bioanalysis

  A DAR sensitive hybrid LBA-LC-MS/MS assay for quantitation of conjugated payload from a non-cleavable ADC in human serum

• Breast cancer research : BCR

  삼중음성유방암에서 Trop2 지향 항체-약물 접합체 사시투주맙 고비테칸과 TRAIL 효능제 병용의 협력적 세포사멸